Decoding coronary artery calcification: metabolic reprogramming features and a promising circulating biomarker PXDN (opens in new tab)

BackgroundCoronary artery calcification (CAC) is a strong predictor of cardiovascular disease, yet metabolism-related molecular alterations underlying CAC remain poorly understood. This study aimed to explore metabolism-related transcriptional changes associated with CAC and identify potential circulating biomarkers for early detection and risk stratification.MethodsTwo transcriptomic datasets, GSE58150 (discovery cohort) and GSE211752 (validation cohort), were analyzed after excluding poor-q...