Stage-specific disruption of erythropoiesis leads to anemia in newly diagnosed multiple myeloma patients (opens in new tab)

BackgroundMultiple myeloma (MM) associated anemia affects over 60% of patients and correlates with poor prognosis. While most studies focus on the impact of microenvironment on erythropoiesis in MM, the stage-specific erythroid cell defects and their underlying molecular mechanisms remain poorly characterized.MethodClinical data were collected from 300 patients with newly diagnosed multiple myeloma (NDMM) and 300 healthy controls. Phenotypic and transcriptomic profiles of bone marrow early an...