Development of the membranous labyrinth in E9.5 to E14.5 C57BL/6N mouse embryos. Stage specific metric and descriptive reference data and their use for identifying malformations (opens in new tab)

Morphological phenotyping of genetically engineered or experimentally challenged mice is the first step in researching the causality of congenital malformations. Especially for spatially complex structures like the inner ear, this is challenging. Our study aims at providing detailed anatomic descriptions and metric information on the membranous labyrinth of mouse embryos from the first demarcation of the otic vesicle to the transition to fetal life. It further intends to use these data as ref...