CDKN2A/2B gene variants and gene-environment interactions increase the risk of gestational diabetes mellitus in Chinese women (opens in new tab)

IntroductionThis study investigates the association between the cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) gene and gestational diabetes mellitus (GDM) in Chinese women, with a focus on potential gene-environment interactions.MethodsA case-control study was conducted with 1,566 pregnant women from Beijing, Wuhan, and Zunyi, China. Blood samples were analyzed using targeted next-generation sequencing. Logistic regression was applied to examine the relationship between gene polymorphis...