Targeting lung cancer: synergistic therapeutic strategy of cuproptosis and immunogenic cell death (opens in new tab)

Cu, a common essential trace element in the human body, is involved in multiple physiological and pathological processes. Cuproptosis, a recently proposed form of cell death, is triggered by Cu overload. It primarily targets lipoylated proteins in the tricarboxylic acid cycle, induces proteotoxic stress, and impairs mitochondrial respiration. Cuproptosis can induce immunogenic cell death (ICD), which triggers adaptive immunity in response to cellular stress, thereby stimulating an immune resp...