Modeling the spatiotemporal properties of crosstalk between RyR-mediated and IP3R-mediated local Ca2+ release (opens in new tab)

Ryanodine receptors (RyR) and IP3 receptors (IP3R) are Ca2+ release channels expressed on the endoplasmic/sarcoplasmic reticulum (ER/SR) membrane in various cell types. Both the spatial localization and the distinct gating properties of these channels contribute to the diverse cellular functions controlled by intracellular Ca2+ signaling. It is known that both RyR2s and IP3R2s are expressed on the SR membrane of ventricular cardiomyocytes and that the expression of IP3R2s on the SR is increas...