Aging-associated transcriptional programming of mitochondrial respiration in alveolar type II epithelial cells (opens in new tab)

Alveolar type II epithelial cells (AT2), notable for their high mitochondria content, are essential for maintaining pulmonary homeostasis. However, how mitochondrial function was transcriptionally programmed during AT2 aging remains poorly understood. Here, we used single-cell transcriptome data from 28 healthy human lungs spanning various ages to systematically profile age-related transcriptional changes. Our data suggest that most classical aging markers remained stable with no significant ...