Decoding atherosclerosis through lactylation: multi-omics integration with experimental validation (opens in new tab)

BackgroundAtherosclerosis (AS) remains a major cause of cardiovascular morbidity and mortality. Lactylation—a recently described post-translational modification linking cellular metabolism to gene regulation—has been implicated in vascular inflammation, yet its roles in AS are not fully defined.MethodWe modelled AS by exposing HUVECs to oxidised LDL and performed data-independent proteomics. Public AS transcriptomes were integrated and batch-corrected; lactylation-related genes (LRGs) were pr...