Defining the urine proteome in boys with posterior urethral valves: a pilot study (opens in new tab)

IntroductionPosterior urethral valves (PUV) is the most common cause of congenital bladder outlet obstruction and a major etiology of end-stage kidney disease in boys. There are significant knowledge gaps about the pathogenesis and prognostic indicators of kidney and bladder dysfunction in boys with PUV.MethodsWe utilized liquid chromatography-tandem mass spectrometry to analyze the urine proteome in a pilot cohort of 20 boys with PUV compared to 20 unaffected controls, with a focus on estima...