Cancer cells metastasize in several types of cancer via two distinct routes, probably based on mechanical signals (opens in new tab)

Tumor diseases pose an enormous health threat when they become malignant, as in the process of metastasis. Cancer metastasis has been extensively studied in the past, but attention has been focused primarily on the established intraluminal metastasis route. Research efforts have concentrated on the complex mechanisms behind this process based on biochemical and molecular analyses. Therefore, a comprehensive knowledge of the mechanobiological principles of cancer metastasis and the identificat...