Liuwei dihuang decoction attenuates intervertebral disc degeneration by inhibiting TRPA1-Mediated ferroptosis in endplate chondrocytes (opens in new tab)

IntroductionLiuwei Dihuang Decoction (LWDHD) is a well-known traditional Chinese medicine formula, which occupies an important position in clinical TCM practice. This study aimed to elucidate the therapeutic mechanism of LWDHD against Intervertebral Disc Degeneration(IVDD), with a specific focus on its role in preventing endplate chondrocyte degeneration and its interaction with the TRPA1-ferroptosis axis.MethodsThe components of LWDHD were first characterized using high-performance liquid ch...