Enhancement of chemotherapeutic efficacy via non-canonical autophagy induced by Olea europaea in human model of lung adenocarcinoma cells (A549) (opens in new tab)

IntroductionLung cancer (LC) remains a leading cause of cancer-related mortality worldwide, with poor prognosis and limited therapeutic efficacy due to drug resistance and off-target effects. Combining natural compounds with conventional chemotherapy is emerging as a promising strategy to enhance anticancer activity while reducing toxicity.MethodsWe investigated the effects of an olive fruit extract from Olea europaea L. (OE) combined with 5-fluorouracil (5-FU) or cisplatin (CIS) on human lun...