Novel mouse line with D277N mutation in the Plau gene displays autism spectrum disorder-like traits (opens in new tab)

IntroductionGenetic technologies provide an opportunity to study the molecular basis of a wide range of hereditary pathologies, including mental disorders. Reproducing of potentially pathogenic genomic variants in cellular and animal models allows establishing their functional significance and possible mechanisms of involvement in the pathogenesis of certain disorders.MethodsIn this study, a genetic variant of urokinase type plasminogen activator (uPA, gene Plau) was modeled in mice using CRI...