Association of baPWV and CD34+ progenitor-derived exosomal hsa_circ_0093884 with Alzheimer’s disease: mechanistic insights into the miR-375/SIX4 axis (opens in new tab)

BackgroundVascular aging plays a key role in the pathogenesis of Alzheimer’s disease (AD). This study evaluated the diagnostic value of arterial stiffness and endothelial progenitor CD34+ progenitor-derived exosomal circRNAs (EPC-Exos circRNAs) in AD, and examined their associations with Comprehensive Geriatric Assessment (CGA) measures.MethodsWe measured brachial-ankle pulse wave velocity (baPWV) and conducted CGA in subjects with AD (n = 58), mild cognitive impairment (MCI, n = 31), and non...