The innate immune mediator group IIA secreted phospholipase A2 modulates lipid droplet formation in prostate cancer cells (opens in new tab)

IntroductionWe and others have shown that elevated human Group IIA secreted phospholipase A2 (hGIIA) has both catalysis-dependent and -independent functions that are associated with both acute and chronic inflammatory disorders including cancer. Our novel inhibitors that selectively block hGIIA’s catalysis-independent function slow tumor growth in animal models via interaction with vimentin. The mechanism of this interaction and its consequences for cancer aggressiveness remains unexplored.Me...