N-salicyloyl tryptamine derivative ameliorates spermatogenic dysfunction in obese mice by attenuating insulin resistance, enhancing Sertoli cell glycolysis, and inhibiting apoptosis: an in vivo and in vitro study (opens in new tab)

BackgroundObesity impairs male reproductive function, yet effective protective strategies are limited. Compound 51 is a novel N-salicyloyl tryptamine derivative whose role in spermatogenic function is unknown. This study aimed to determine whether it protects against obesity-induced spermatogenic dysfunction.MethodsEmploying a combined in vivo and in vitro approach, we first evaluated compound 51 in a high-fat diet-induced obese mouse model, assessing systemic metabolism, reproductive phenoty...