Altered brain vascularization and transcriptional changes in embryos lacking ABCA1 support a role of cholesterol in brain angiogenesis (opens in new tab)

IntroductionLipoproteins are the main lipid carriers in extracellular fluids and mediate the exchange of hydrophobic molecules between cells and their environment in animals, including cholesterol. Lipoprotein metabolism has been implicated in the regulation of angiogenesis, suggesting that cholesterol is important for this process, but a direct role for this lipid has not been unequivocally demonstrated, particularly in the central nervous system (CNS).MethodsHere, we used genetic and pharma...