NELL-1: role and mechanisms in disease pathogenesis and development (opens in new tab)

NELL-1 (NEL-like protein 1) is a multifunctional secreted glycoprotein that has been implicated in a variety of biological processes, including skeletal development, immune regulation, and tumorigenesis. Despite its significance, the regulatory mechanisms of NELL-1 across different tissues, the diversity of its signaling pathways, and its context-dependent roles in disease are not fully elucidated. This gap in understanding hinders the systematic development and clinical translation of potent...