Deciphering the role of per- and polyfluoroalkyl substances in prostate cancer: a multi-omics and computational toxicology approach (opens in new tab)

BackgroundPer- and polyfluoroalkyl substances (PFAS), persistent environmental contaminants, are associated with increased Prostate cancer (PCa) risk. However, their molecular mechanisms are poorly defined.MethodsWe employed a comprehensive computational and experimental framework. The toxicological profiles of PFOA and PFOS were predicted. Shared molecular targets between PFAS and PCa were identified by integrating toxicogenomic and transcriptomic data, followed by protein-protein interactio...