Transcriptomic profiling and RANKL/RANK/OPG-mediated osteoclastogenesis in zebrafish larvae under simulated microgravity conditions (opens in new tab)

IntroductionMicrogravity is one type of external stimulus that affects bone homeostasis and bone development. This study investigates the molecular drivers of these effects in order to more fully understand the cellular communication network between bone cells when bone homeostasis is perturbed.MethodsThe transcriptional responses of bone-related genes in zebrafish larvae (Danio rerio) when exposed to simulated microgravity (SMG) using a Random Positioning Machine were analysed. Larvae were i...