3D Ultrastructural segmentation of human microvasculature reveals new insights in pericyte-endothelial cell interactions (opens in new tab)

IntroductionCapillary structure remains incompletely characterized at the nanoscale level. Advances in 3D electron microscopy datasets provide new opportunities to systematically examine microvascular architecture and cellular interactions.MethodsWe performed 3D image segmentation of human cerebral cortex microvasculature using the publicly available H01 Release dataset. This initial analysis focused on descriptive and quantitative characterization of the basement membrane, peg-and-socket cel...