An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations (opens in new tab)

AimWe aimed to investigate the association between genes related to disulfidptosis—a form of cell death caused by aberrant disulfide stress and cytoskeletal collapse—and the molecular features of minimal change disease (MCD), the leading cause of primary nephrotic syndrome.MethodsData from the GeneCards and Gene Expression Omnibus (GEO) databases were integrated to systematically analyze disulfidptosis-related genes in MCD. Machine learning approaches—including generalized linear model (GLM),...