Epigenetic regulation in early embryogenesis: mechanisms, developmental programming, and transgenerational implications (opens in new tab)

Epigenetics are heritable features of gene expression without changes in the underlying DNA sequence and involve chemical modifications to DNA and histone proteins. The role of these mechanisms is central to the regulation of genes, determination of cell fate, embryonic development, and susceptibility or resistance to disease. Recent advances in low-input and single-cell sequencing technologies have revolutionized understanding of the early embryonic epigenome. These approaches reveal a highl...