ChREBPα: a central metabolic sensor driving lipid droplet renewal in preimplantation mouse embryos (opens in new tab)

BackgroundLipid droplets (LDs) are abundant during early embryogenesis; however, yet, the mechanisms that govern their synthesis, maintenance, and functional relevance remain poorly defined. This study aimed to investigate how early mouse embryos sense lipid depletion and activate adaptive metabolic responses to sustain developmental progression.MethodsMouse zygotes were mechanically delipidated and cultured under fatty acid–free conditions, and LD recovery was quantified by BODIPY staining a...