Pyroptosis in epilepsy: from pathophysiological mechanisms to therapeutic strategies (opens in new tab)

Epilepsy affects millions of individuals worldwide, however, approximately one-third of patients exhibit pharmacoresistance to currently available antiseizure therapies, underscoring an urgent unmet need for novel mechanism-based therapeutic strategies. Pyroptosis, a Gasdermin-mediated proinflammatory cell death, has recently been implicated as a pivotal driver of epileptogenesis and disease progression. This narrative critically evaluates emerging preclinical and clinical evidence linking py...