CGRP-mediated neuro-vascular-pulp cell crosstalk is essential for dental pulp repair (opens in new tab)

IntroductionThe repair of dental pulp injury is the cornerstone of vital pulp therapy. Traditional research has predominantly focused on the roles of immune cells, vascular endothelial cells, and dental pulp stem cells, often overlooking the active regulatory functions of the sensory neural network. Sensory nerve fibers constitute nearly 40% of the dental pulp volume, and their released neuropeptides, such as calcitonin Gene-Related Peptide (CGRP), are hypothesized to coordinate the repair pr...