Emerging functions of m6A-modified circRNAs and their targeting strategies in lung cancer (opens in new tab)

Lung cancer, especially non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related morbidity and mortality worldwide, largely due to challenges in early diagnosis, pronounced tumor heterogeneity, and frequent therapeutic resistance. N6-methyladenosine (m6A), the most prevalent RNA epigenetic modification, participates in tumorigenesis and progression by regulating various aspects of RNA metabolism. Circular RNAs (circRNAs), characterized by their covalently closed loop stru...