Integrated multi-omics characterization of SPTBN2 overexpression reveals its pro-tumorigenic role and immune microenvironment remodeling in colorectal cancer (opens in new tab)

BackgroundColorectal cancer (CRC) is highly heterogeneous, which limits the consistency of benefit from immune checkpoint blockade. SPTBN2 has recently been implicated as a candidate biomarker in CRC, but its cross-omics features and potential links to the tumor immune microenvironment remain insufficiently characterized.MethodsWe integrated multi-omics profiles from TCGA and GEO, including transcriptomics and DNA methylation, to evaluate SPTBN2 expression patterns, prognostic relevance, and ...