Anti-fatigue mechanism of Dendrobium officinale pseudobulbs from different growth durations against chronic fatigue syndrome in mice and analysis of their active chemical components (opens in new tab)

To investigate the differential efficacy of Dendrobium officinale pseudobulb alcohol extracts from varying growth durations against chronic fatigue syndrome (CFS) in mice, elucidate the underlying anti-CFS mechanisms, and identify the pharmacologically active components responsible. An ICR mouse model of CFS was established using the forced swimming test (FST). Behavioral characteristics, physiological phenotypes, biochemical parameters, and plasma metabolomics profiles were assessed. Concurr...