Cell division during Xenopus gastrulation influences neuroectoderm patterning (opens in new tab)

Oriented cell division is emerging as a fundamental morphogenetic mechanism driving tissue elongation and axis formation. Although Xenopus laevis embryos can undergo gastrulation and neurulation in the absence of cell division, the specific contribution of mitosis during gastrulation remains poorly defined. Here, we systematically examine the role of cell division during gastrulation in neural plate formation and anterior–posterior (A–P) patterning. Using Hydroxyurea and Aphidicolin (HUA) to ...