The context-dependent role of the dsRNA response in linking A-to-I editing and ADAR to normal hematopoiesis and leukemia (opens in new tab)

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR), contributes to cellular RNA homeostasis. By recoding protein, inducing alternative splicing and regulating non-coding RNAs, ADAR-mediated editing influences diverse biological processes including development, homeostasis and pathogenesis. In particular, ADAR-mediated A-to-I editing prevents endogenous double-stranded RNAs from improperly activating pattern recognition receptors and downstream inn...