Immune dysregulation in gestational diabetes mellitus: placental downregulation of CXCL9 and IL1RL1 and altered immune cell infiltration (opens in new tab)

BackgroundImmune dysregulation is implicated in pregnancy complications, particularly gestational diabetes mellitus (GDM). This study aimed to identify immune-related genes and characterize immune cell infiltration in GDM placentas.MethodsmRNA transcript expression profiles were retrieved from the GSE70493 dataset and integrated with immune-related genes (IRGs) extracted from the ImmPort database. Differentially expressed immune-related genes (DIRGs) were identified, followed by functional en...