ZDHHC5 interacts physically and functionally with DLG1 at primary cilia and regulates ciliary length and kidney morphology (opens in new tab)

IntroductionPrimary cilia are critical sensory organelles whose structure and composition are tightly regulated. The Scribble polarity complex protein DLG1 has recently been implicated in controlling both ciliary protein composition and length in mouse kidney epithelial cells. In addition, the palmitoyl transferase ZDHHC5 localizes to primary cilia and negatively regulates their length. However, the molecular mechanisms underlying DLG1-mediated ciliary regulation and its interaction network r...