Systematic analysis of programmed cell death–related genes in sepsis reveals immune heterogeneity and enables patient stratification (opens in new tab)

BackgroundSepsis is a life-threatening syndrome characterized by dysregulated host response to infection. Programmed cell death (PCD) pathways, including apoptosis, necroptosis, and pyroptosis, play a critical role in sepsis pathophysiology. However, the crosstalk between PCD, metabolic reprogramming, and immune heterogeneity remains poorly understood.MethodsWe analyzed transcriptomic data from the GSE57065 and GSE95233 datasets. Differentially expressed genes (DEGs) were intersected with pro...