A mechanistic study on the enhanced antihypertensive effects of a Dendrobium officinale compound combined with Western antihypertensive drugs in spontaneously h... (opens in new tab)

BackgroundIn our previously published research, we reported that the combination of Dendrobium Officinale Compound (DOC) and antihypertensive medications (irbesartan and amlodipine besylate) significantly and stably regulates blood pressure in spontaneously hypertensive rats (SHRs). This study aims to further explore the unique mechanisms and pathway networks underlying the antihypertensive effects of this combination therapy at the molecular level, based on serum and ileocecal contents metab...