Systems-level analyses and clinical validation highlight CD53 as a diagnostic and prognostic marker in lung adenocarcinoma (opens in new tab)

BackgroundLung adenocarcinoma (LUAD) is the most common subtype of lung cancer, often diagnosed at advanced stages with poor prognosis. CD53, a tetraspanin involved in immune regulation, has an unclear role in LUAD.MethodsFive GEO LUAD transcriptomic datasets were integrated and batch-corrected. Differential expression and weighted gene co-expression network analyses identified LUAD-associated genes. Machine learning (Elastic Net) selected core predictive genes. Immune infiltration analysis, ...