Therapeutic vulnerability shaped by the microenvironment: multi-omics and AI biomarkers for precision surgical planning in gastrointestinal tumors (opens in new tab)

BackgroundTherapeutic vulnerability in gastric cancer is profoundly influenced by the tumor microenvironment (TME), yet reliable and clinically actionable preoperative indicators remain insufficient.MethodsWe developed and validated an artificial intelligence–driven multi-omics TME score (DLRS/TMEscore) by integrating CT-derived imaging features with transcriptomic, immunohistochemical, and molecular profiling. The score was evaluated for its associations with survival outcomes, benefit from ...