HMGB1 regulates mitochondrial structure and reactive oxygen species balance during the transition from naïve to primed pluripotency (opens in new tab)

IntroductionEmbryo implantation is characterized by the process of naïve-to-primed pluripotency transition in epiblast cells, involving an anabolic boost, mitochondrial remodeling, and increased proliferation. Yet, the molecular mechanisms underlying these extensive changes remain poorly understood. High mobility group box 1 (HMGB1) is a non-histone, redox-sensitive chromatin protein involved in diverse cellular processes, however its role in pluripotency control has not been fully characteri...