Reorganization of E-cadherin into apical spot junctions mediates interlineage adhesion between epithelial and germline cells (opens in new tab)

During development, epithelia must coordinate morphogenesis with neighboring cell lineages to drive structural remodeling of organ systems. How adhesion between epithelial and other cell types is established and maintained remains poorly understood. Using the Drosophila ovary as an in vivo model, we show that anterior follicle cells (AFCs) undergo epithelial plasticity to establish and maintain adhesion with germline nurse cells during late oogenesis. As AFCs spread over the nurse-cell compar...