Metabolic reprogramming and plasticity of cancer stem cells (opens in new tab)

Numerous studies in cancer biology have provided evidence of the remarkable plasticity of cancer stem cells (CSCs). These cells play a key role in tumor initiation, metastasis, and resistance to treatment. One of the most critical features of CSCs is the epithelial–mesenchymal transition, which underlies their phenotypic plasticity. CSCs can modify their metabolic profile through interactions with cancer-associated fibroblasts, tumor-associated macrophages, and regulatory t-cells. CSCs create...