Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway (opens in new tab)

BackgroundHair follicle aging is driven by COL17A1 proteolysis in hair follicle stem cells (HFSCs). Mesenchymal stem cell (MSC)-derived exosomes show promise in tissue regeneration, but their effects on COL17A1 and hair follicle aging remain unexplored.MethodsExosomes isolated from human umbilical cord MSCs (hUC-MSCs) were evaluated in H2O2-induced senescent human dermal papilla cells (hDPCs), ex vivo human hair follicle organ culture, and C57BL/6 mouse hair regeneration model. Small RNA sequ...