Longitudinal changes in the phenotypic profile of circulating extracellular vesicles in healthy individuals (opens in new tab)

BackgroundExtracellular vesicles (EVs) are emerging as valuable biomarkers in clinical diagnostics. Yet, the natural biological variation in EV concentration and phenotype among healthy individuals and across longitudinal time points remains insufficiently characterized, complicating interpretation and reproducibility in biomarker studies.ObjectiveTo assess longitudinal (day-to-day and week-to-week) intra-individual and inter-individual variation in circulating EVs from healthy donors using c...