The role of IL-33/ST2 signaling in female reproductive diseases (opens in new tab)

Female reproductive tissues repeatedly undergo controlled inflammation, immune adaptation, and tissue repair. Interleukin-33 (IL-33) and its receptor suppression of tumorigenicity 2 (ST2) sit at the center of these processes, but their roles in reproductive disease have often appeared contradictory. In this review, we integrate current evidence and propose that IL-33/ST2 signaling is not simply pro-inflammatory or anti-inflammatory. Instead, it functions as a context- and stage-dependent regu...