Epigenetic regulation of the β-catenin pathway in cadmium-induced colorectal cancer progression and chemoresistance (opens in new tab)

Colorectal cancer (CRC) has become a global health issue, as exposure to toxic metals (lead, chromium, cadmium, aluminum, copper, arsenic, and mercury) has all been implicated in its development and progression through interference with the mechanisms of cell proliferation and death. Recent research suggests that cadmium (Cd) and other metals disrupt normal cellular homeostasis through epigenetic changes, particularly modifying the β-catenin signaling pathway, an important key regulator of ce...