Understanding the link between PMN-MDSCs and CXCL8-CXCR1/2 axis in primary myelofibrosis (opens in new tab)

Emergency myelopoiesis in cancer and chronic inflammation leads to the accumulation of myeloid-derived suppressor cells (MDSCs) which localize at tumor sites or areas of chronic inflammation, serving as suppressor cells. Besides reducing the cytotoxic functions of T/NK cells, these cells are major players of the inflammatory process that characterizes the onset and progression of cancer. Inflammation is thought to play a relevant role in the progression of primary myelofibrosis (PMF) and rece...