Ubiquitination mediated by RING-type E3 ligases in the progression of digestive system tumors: mechanistic insights and potential therapeutic strategies (opens in new tab)

Ubiquitination is a core mechanism for the precise regulation of protein fate, closely related to the occurrence and development of many diseases. As the most critical enzymes in the ubiquitination process, really interesting new gene (RING)-type E3 ubiquitin ligases play an important role in regulating the malignant behaviors of tumor cells. As tumor promoters or suppressors, different types of RING-type E3 ligases have shown various prognostic values in cancer patients. This review provides...