MFGE8-primed fibroblasts reprogram the immunosuppressed microenvironment to promote diabetic wound healing (opens in new tab)

BackgroundChronic diabetic ulcers exhibit a dysregulated immune microenvironment characterized by aberrant leukocyte responses and dysfunctional fibroblast activation. Identifying molecular regulators of fibroblast-driven immune responses may provide therapeutic targets to restore effective wound repair in these chronic wounds.MethodsBulk RNA-seq (GSE199939) and scRNA-seq (GSE165816) datasets from human DFUs were integrated to identify alterations in MFGE8 expression in wound fibroblasts. The...