Ferroptosis-pyroptosis crosstalk signature as prognostic biomarkers and therapeutic targets in sepsis-induced ARDS (opens in new tab)

BackgroundAcute respiratory distress syndrome (ARDS) is a severe complication of sepsis with high mortality. Ferroptosis and pyroptosis are two distinct forms of regulated cell death that have been implicated in sepsis-induced organ dysfunction. However, the crosstalk between these 2 cell death pathways in sepsis-induced ARDS remains unclear.MethodsWe analyzed gene expression data from sepsis and ARDS patients to identify ferroptosis-pyroptosis crosstalk genes. Single-cell RNA sequencing was ...