p300: expanding beyond acetylation to mastermind lactylation-dependent tumorigenesis (opens in new tab)

The transcription coactivator p300 is canonically recognized as a histone acetyltransferase that orchestrates chromatin remodeling and gene expression. However, recent breakthroughs have expanded the catalytic landscape of p300 beyond acetylation to include lactylation, a metabolic stress induced modification driven by lactate accumulation. As a principal lactyl-transferase, p300 acts as a sensor of the Warburg effect, directly translating cellular metabolic status into epigenetic regulation....