Epigenetic dysregulation in mycosis fungoides and sézary syndrome (opens in new tab)

Cutaneous T-cell lymphomas (CTCL), including mycosis fungoides (MF) and Sézary syndrome (SS), remain challenging to diagnose at early stages and to manage durably. Although staging and classification have improved, early MF can mimic benign inflammatory dermatoses, and advanced disease frequently develops resistance to standard therapies, including histone deacetylase (HDAC) inhibitors. Here, we summarize how aberrant DNA methylation and histone modifications contribute to CTCL pathogenesis, ...